Redox potentiometry studies of particulate methane monooxygenase: support for a trinuclear copper cluster active site.
نویسندگان
چکیده
منابع مشابه
Facile O-atom insertion into C-C and C-H bonds by a trinuclear copper complex designed to harness a singlet oxene.
Two trinuclear copper [Cu(I)Cu(I)Cu(I)(L)](1+) complexes have been prepared with the multidentate ligands (L) 3,3'-(1,4-diazepane-1,4-diyl)bis(1-((2-(dimethylamino)ethyl)(methyl)amino)propan-2-ol) (7-Me) and (3,3'-(1,4-diazepane-1,4-diyl)bis(1-((2-(diethylamino) ethyl)(ethyl) amino)propan-2-ol) (7-Et) as models for the active site of the particulate methane monooxygenase (pMMO). The ligands wer...
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Copper-exchanged zeolites with mordenite structure mimic the nuclearity and reactivity of active sites in particulate methane monooxygenase, which are enzymes able to selectively oxidize methane to methanol. Here we show that the mordenite micropores provide a perfect confined environment for the highly selective stabilization of trinuclear copper-oxo clusters that exhibit a high reactivity tow...
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Particulate methane monooxygenase (pMMO) is a membrane-bound enzyme that catalyzes the oxidation of methane to methanol in methanotropic bacteria. Understanding how this enzyme hydroxylates methane at ambient temperature and pressure is of fundamental chemical and potential commercial importance. Difficulties in solubilizing and purifying active pMMO have led to conflicting reports regarding it...
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Particulate methane monooxygenase (pMMO) catalyzes the oxidation of methane to methanol in methanotrophic bacteria. As a copper-containing enzyme, pMMO has been investigated extensively by electron paramagnetic resonance (EPR) spectroscopy, but the presence of multiple copper centers has precluded correlation of EPR signals with the crystallographically identified monocopper and dicopper center...
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I n this issue of PNAS, Schoonheydt, Solomon, and coworkers (1) definitively characterize the structure of the Cu-ZSM-5 site that oxidizes methane to methanol. With the successful correlation of a specific copper-oxy structure to such reactivity, the importance of this work extends beyond hydrocarbon oxidation on zeolites. This breakthrough potentially has farreaching implications in both the f...
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ورودعنوان ژورنال:
- Angewandte Chemie
دوره 46 12 شماره
صفحات -
تاریخ انتشار 2007